Hi Sylvia, I am on methotrexate injection and sulphasalazine plus pain relief. I found methotrexate tabs did cause some minor gum problems but no probs on inj till last week and now have small ulcer. I tend now not to have crunchy food and this seems to help a lot (not on sops yet) If you have a Rh nurse they are a great source of info and help. Good luck, Nan